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Histamine H3 receptor as a potential target for cognitive symptoms in neuropsychiatric diseases

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2 Mitochondria and ROS 2.1 The structure and functions of mitochondria Mitochondria are ubiquitous intracellular organelles present in nearly all eukaryotes and involved in multiple aspects of cellular life, with a primary role in energy production

Specifically, copper depletion limits GPX4 protein expression and reduces cellular sensitivity to ferroptosis inducers, establishing a direct link between copper levels and ferroptosis [128]